Robert and AJ make their way to Mississippi for an action-packed reunion. Back in New York, Louis opens the door to an unexpected visitor.

Meredith and the team are focused on helping Owen’s sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan…

Meredith struggles to come up with a new plan for Owen’s sister. Jo makes a surprising choice regarding Alex, and Andrew’s sister’s controversial research leads to a shocking discovery.