Betty sees her life has been a sham for years.

Debra makes a decision about John. In Ohio, John captures the attention of Detective Dennis Luken.

A look at how John operates while Debra tries to move forward.

John and Debra’s relationship comes to a head in an unexpected way.

The police question Drs. Pratt and Gallant about a rampage at the diner across from the ER. Dr. Lewis befriends her teen admirer, a cancer patient.

A-N-X-I-E-T-Y seizes Frasier at the National Spelling Bee, where his son Frederick is a leading competitor.

The First Wave breaks into a mental hospital and cures a long-term patient suffering from schizophrenia. When the Fringe team investigates, Olivia discovers that the group’s leader has one of…

Grissom and Catherine investigate the murder of a despised comic who died onstage, apparently after drinking from a tainted bottle of water. The case grows more puzzling when a 15-year-old…

Grissom and Catherine investigate the murder of a despised comic who died onstage, apparently after drinking from a tainted bottle of water. The case grows more puzzling when a 15-year-old…

The CSI team must investigate one of their own when Langston is accused by a former colleague of being part of the Dr. Jekyll murders, on part one of a…

Toby’s old friend approaches him ready to blow the whistle on his employer’s violations of environmental laws; staff pranks abound on Amy’s first day at the office; Abbey charges Amy…

Kate and Sawyer divulge dark secrets to each other while tracking a renegade boar that Sawyer swears is purposely harassing him. Hurley and Sayid worry that Charlie is losing it…

The squad tracks down a serial killer who has been mutilating women; Ham is temporarily partnered with Butch during Bobby’s absence; Earl tries to persuade Grace to help Leon.

T-Bag digs deep and finds his ‘nice-side’ with the help of a psychiatrist. Michael, Lincoln, and Sarah get their hands on evidence needed to bring down The Company, while Kellerman…

An unlikely alliance forms between Bellick and Sucre while Michael is determined to face the president. T-Bag gets into some trouble when he loses his luggage and C-Note faces major…

Bellick gets a taste of the medicine he gave out when he was the Captain and Agent Mahone’s ex-wife makes another appearance.

As eight hours has passed since the escape, Michael, Lincoln, Sucre, C-Note and Abruzzi attempt to evade their seekers. Bellick is forced to relinquish the command of the search party…

As Thanksgiving, Christmas and New Year’s pass, Miranda gets a visit from her father, William who disapproves of her choices in life. Mark and Lexie cope with an arrival of…

When Meredith and Lexie’s father, Thatcher, returns to the hospital with a failed liver, it’s up to Meredith to save his life. Meanwhile, Izzie empathizes with a patient riddled with…

Thatcher Grey, Meredith and Lexie’s father, returns to Seattle Grace with stomach pains and a new, twenty-something tattooed girlfriend, Danielle. Meanwhile, Alex clashes with the new OB, Dr. Lucy Fields,…

Amelia and Koracick tackle a daunting surgery on Catherine while Richard and Jackson hope for the best. Meanwhile, Richard urges Meredith to visit her father, Thatcher, before his time is…

Stan seeks out Francine’s birth parents because her visiting adoptive parents annoy him so much. But they don’t annoy Steve, especially after they give him fireworks.

As preparations continue for Meredith and Derek’s wedding, Izzie receives a surprise hospital visit from her handful-of-a-mother, Robbie. Meanwhile, a newly sober Thatcher visits his daughters, Meredith and Lexie, in…

The interns finally take their first year medical exams, the biggest test of their careers, and one of them is ill-prepared. Callie grows more suspicious of George and Izzie. The…

The race between the attending physicians for the Chief of Surgery position heats up after a new competitor enters the fray. They soon realize that the new surgeon, Colin Marlow,…

Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke’s. Alex continues to tend to Jane Doe/Ava. Meredith and Derek’s relationship has…

Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke’s. Alex continues to tend to Jane Doe/Ava. Meredith and Derek’s relationship has…

Meredith discovers that Derek has a problem sleeping while her father comes to visit the hospital. George’s father is moving from one surgery to another. A patient named Heather checks…

Cristina and Burke continue to play Uncle until one of them gives in. Derek and Meredith are fighting over the reason for their sleepless nights. Meredith tries to talk to…

Izzie and George’s new-founded relationship results in them having bad sex. Callie’s Chief Resident position is taken away from her, and Bailey is the humble replacement. Meredith can barely handle…

There has been a bus crash and the patients are in the ER. Meredith and Derek’s relationship gets more complicated when he dates a fellow doctor. Meredith’s dad goes to…

Derek and Addison’s relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of…

Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury. Bailey gets in on Andrew’s surgery because she’s worried that her…

Self-esteem is the lesson of the day for Angela’s warped relationship with Jordan, Brian’s unreciprocated devotion to Angela, Rickie’s flair for the dramatic, and Graham’s cooking expertise.

It’s New Year’s Eve and while everyone else is busy making or breaking his or her resolutions, Rickie faces an increasingly difficult situation.

Angela realizes she is over Jordan and is in to someone else. But Brian Cracow catches Rayanne and Jordan on tape having sex.

Jordan asks Brian for help on winning back Angela’s affections; Sharon and Rayanne reach a turning point in their relationship; and Rickie learns that the new girl has a crush…

Homeless people are dying and their bodies are disappearing. Tina rekindles a relationship with a former colleague who is an expert in genetic engineering.