As fateful connection finds its footing, Nellie faces an uncertain future and Sam attempts to make peace with his past.

Sam and Nellie hit the road for a special retreat. Elsewhere, Dante attempts to forge a road to forgiveness after making a crucial mistake.

In the face of uncertainty, Sam turns to Joanna. Elsewhere, a promising new beginning pushes Nellie to her limits.

A series of earth-shattering incidents redefine Sam’s past, present and future. Margot approaches Frank with a desperate ask.

As Barry’s future hangs in peril, Margot makes a risky move, Annette faces a hard truth and both women explore the real meaning of family.

Sam and Nellie’s story comes to a tentative close — but not before one last encore of hopeful, heartbreaking and healing performances.

As Maggie deals with her own trauma, she steps in to help a mother in need. Dean continues to stir the pot with more than one doctor. A patient comes…

Dr. Song launches her pilot program, giving the E.D. a technological facelift. Archer clashes with Charles on a patient faking paralysis. Archer helps a pregnant mother with a heart condition.

Charles and Cuevas clash over the treatment of a paranoid patient. Choi treats a pregnant patient from Asher’s past. Marcel and Taylor help a man who needs a risky neurosurgery.

Scott and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Halstead and Charles question an elderly patient’s Alzheimer’s diagnosis. In an effort to help a…

Halstead helps a patient with long-haul COVID-19 symptoms. Taylor reflects on her dating life when she learns that a patient’s daughter is having an arranged marriage.

Will and Stevie get stuck in the middle of a marital face-off. Dr. Blake’s entire surgical team mysteriously collapses during a liver transplant. Charles encourages Ethan to reconcile with his…

Crockett helps Dr. Blake replace a patient’s liver. Vanessa tries to prove herself. Will continues to pursue the truth about Cooper. Ethan gets closer to returning to life in the…

A husband makes a request following his wife’s death; Dr. Charles tries to reason with a patient who wants to remove his own arm from his body; a child arrives…

A teen patient with abdominal pain firmly refuses any drugs. Meanwhile, Dr. Halstead reconnects with his past when treating a patient; a pregnant woman does everything in her power not…

Dark family secrets emerge when Dr. Rhodes’ father is honored for making a large donation to the hospital. Meanwhile, the Department of Homeland Security arrives when two injured airplane stowaways…

The grand opening of Chicago Med’s emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

Dr. Choi treats a teen mother who abandoned her newborn baby in an alley, as the staffers must make difficult decisions about the teen’s future. Also, a hypochondriac with chest…

Fontana and Green investigate when a bank manager is involved in the robbing of his own bank and learn that his daughter is being held hostage and that he had…

A conservative talk show host involved in a sexual harassment scandal is murdered, but the trail leads to the victim’s wife and an obsessed stalker.