Lena’s ex-boyfriend, Jack Spheer, comes to National City to unveil his big breakthrough in nano-technology, which has the potential to eradicate all diseases. Lena asks Kara to attend Jack’s conference…

Nia’s roommate, Yvette, is attacked by a man targeting Dreamer because he doesn’t like that Dreamer is transgender and wants her to quit being a superhero. Determined to protect her…

Supergirl learns the true depth of Serena’s nefarious plans for Earth. Supergirl, Mon-El and Alura must devise a plan to stop her before Serena gets to Earth. J’onn prepares to…

As Supergirl and Zor-El make their return to National City, they are determined to keep the Phantom Zone behind them and enjoy being superheroes together. Unfortunately, their overzealous efforts backfire,…

When Supergirl needs help, Alex asks Lena and Brainiac to team up. Meanwhile, J’onn questions his decision to quit the DEO. However, after running into Manchester Black, he realizes there…

Kara goes toe-to-toe with Astra when her aunt challenges Kara’s beliefs about her mother. Also, Cat is threatened with being removed as the CEO of CatCo after a hacker exposes…